Key selected publications | Huang Lab
13,000
Citations
47
h-index
120+
Publications
Epigenetics
Optogenetics
Cancer biology
Immunotherapy
Heart development
Cardiac repair
Synthetic biology
DNA methylation
Immunology
Calcium signaling
Biosensor design
Epigenome mapping
Selected from 100+ publications with 10,000+ citations
Perturbation of TET2 condensation promotes genome-wide promiscuous DNA hypomethylation to curtail leukemia cell growth.
Nature Cell Biology 2024
TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.
Nature Aging 2023
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy.
Nature Communications 2023
Optogenetics for transcriptional programming and genetic engineering.
Trends in Genetics 2022 [cover]
Optophysiology: Illuminating cell physiology with optogenetics.
Physiological Reviews. 2022 [cover]
Targeting epigenetic regulatory machinery to overcome cancer therapy resistance.
Seminars in Cancer Biology 2022 [cover]
Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes.
Cancer Research 2021
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety.
Nature Nanotechnology 2021
Circularly permutated LOV2 as a modular photoswitch for optogenetic engineering.
Nature Chemical Biology 2021
Engineering of a bona fide light-operated calcium channel.
Nature Communications 2021
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nature Communications 2020
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Nature Communications 2020 Caffeine‐Operated Synthetic Modules for Chemogenetic Control of Protein Activities by Lifestyle. Advanced Science 2020 [cover] Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science Advances 2020 Intelligent cell-based therapies for cancer and autoimmune disorders. Current Opinions in Biotechnology 2020 Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Nature Communications 2019 p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene 2019 Genetically encoded tags for real time dissection of protein assembly in living cells. Chemical Science 2018 Optical control of membrane tethering and interorganellar communication at nanoscales. Chemical Science 2017 Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis. Journal of Clinical Investigation 2017 Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling. Journal of the American Chemical Society 2017 DNMT3A and TET2 compete and cooperate to repress lineage-specific factors in hematopoietic stem cells. Nature Genetics 2016 A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways. Genome Biology 2016 The histone deacetylase Sirt6 controls embryonic stem cell fate via Tet-mediated production of 5-hydroxymethylcytosine. Nature Cell Biology 2015 Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP proteins in Coprinopsis cinerea. PNAS 2014 Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. PNAS 2014 Connections between TET proteins and aberrant DNA modification in cancer. Trends in Genetics 2014 Stage-Specific Roles for Tet1 and Tet2 in DNA Demethylation in Primordial Germ Cells. Cell Stem Cell 2013 New functions for DNA modifications by TET-JBP. Nature Structural & Molecular Biology 2012 The anti-CMS method for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protocols 2012 The GLIB method for mapping 5-hydroxymethylcytosine genome-wide. Nature Protocols 2012 Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 2011 Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Nature Communications 2020 Caffeine‐Operated Synthetic Modules for Chemogenetic Control of Protein Activities by Lifestyle. Advanced Science 2020 [cover] Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science Advances 2020 Intelligent cell-based therapies for cancer and autoimmune disorders. Current Opinions in Biotechnology 2020 Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Nature Communications 2019 p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene 2019 Genetically encoded tags for real time dissection of protein assembly in living cells. Chemical Science 2018 Optical control of membrane tethering and interorganellar communication at nanoscales. Chemical Science 2017 Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis. Journal of Clinical Investigation 2017 Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling. Journal of the American Chemical Society 2017 DNMT3A and TET2 compete and cooperate to repress lineage-specific factors in hematopoietic stem cells. Nature Genetics 2016 A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways. Genome Biology 2016 The histone deacetylase Sirt6 controls embryonic stem cell fate via Tet-mediated production of 5-hydroxymethylcytosine. Nature Cell Biology 2015 Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP proteins in Coprinopsis cinerea. PNAS 2014 Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. PNAS 2014 Connections between TET proteins and aberrant DNA modification in cancer. Trends in Genetics 2014 Stage-Specific Roles for Tet1 and Tet2 in DNA Demethylation in Primordial Germ Cells. Cell Stem Cell 2013 New functions for DNA modifications by TET-JBP. Nature Structural & Molecular Biology 2012 The anti-CMS method for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protocols 2012 The GLIB method for mapping 5-hydroxymethylcytosine genome-wide. Nature Protocols 2012 Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 2011 Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010
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